QYRA® is an oral supplement featuring a clinically validated bioactive collagen peptide formulation (Verisol®). It is designed to provide the necessary amino acid precursors to support dermal matrix regeneration, fibroblast activity, and collagen synthesis [1].

• Active Ingredient: 2.5 g Verisol® Bioactive Collagen Peptides
• Format: Oral liquid vials
• Dosing: One vial daily, preferably in the evening to align with nocturnal cellular repair cycles.
• Minimum Duration: 12 weeks (based on the clinically relevant window observed in Verisol® trials) [1].

The efficacy of Verisol® is supported by double-blind, placebo-controlled trials demonstrating its ability to influence the skin's extracellular matrix.

• Fibroblast Stimulation: Provides specific peptides recognized by fibroblast receptors, theoretically stimulating the production of new extracellular matrix
components [1].
• Collagen Production: May support the enhancement of collagen type I and procollagen type I production [1].
• Dermal Density: Clinical studies have shown statistically significant improvements in skin elasticity and reductions in wrinkle volume after 4 to 8 weeks of daily intake [1] [2].

QYRA® is positioned as a supportive adjunct to dermatological procedures that rely on percutaneous collagen induction or tissue remodeling. It is not a standalone treatment for dermatological conditions.

Indications: Rapid facial volume loss, skin laxity, and decreased dermal density associated with GLP-1 agonist therapies (e.g., Semaglutide, Tirzepatide). Combine with:

• Biostimulatory fillers (e.g., Poly-L-lactic acid, Calcium hydroxylapatite)
• Energy-based skin tightening (e.g., Radiofrequency, Ultrasound) QYRA Protocol
• Daily use initiated concurrently with aesthetic interventions and continued for 6–12 months. Clinical Rationale:
• Patients experiencing rapid weight loss often suffer from compromised skin structural integrity. QYRA® provides a consistent supply of collagen precursors to support the dermal matrix during the remodeling phase initiated by biostimulators or energy-based devices.

Indications: Skin resurfacing, tightening, and rejuvenation. Combine with:

• Fractional CO2 laser
• Radiofrequency (RF) microneedling QYRA Protocol:
• Start 2 weeks pre-procedure to optimize baseline amino acid availability.
• Continue 8–12 weeks post-procedure. Clinical Rationale:
• These procedures induce controlled thermal injury to stimulate neocollagenesis. While direct clinical trials on Verisol® post-laser are limited, providing oral collagen peptides theoretically supports the increased metabolic demand for collagen synthesis during the recovery and remodeling phases [3].

Indications: Fine lines, reduced elasticity, and textural irregularities. Combine with:

• Standard Microneedling (Dermapen, etc.) QYRA Protocol:
• Daily use for 12–24 weeks, encompassing the treatment series. Clinical Rationale:
• Microneedling relies entirely on the body's natural wound-healing cascade to produce new collagen [4]. QYRA® acts as a nutritional adjunct, ensuring the availability of specific peptides required for optimal extracellular matrix formation.

Indications: Hair thinning, poor shaft quality, and mild alopecia. Combine with:

• Platelet-Rich Plasma (PRP) therapy
• Topical Minoxidil QYRA Protocol:
• Daily use, ongoing (minimum 6 months). Clinical Rationale:
• Emerging evidence suggests that specific bioactive collagen peptides may positively influence hair thickness and the proliferation of human hair follicle cells [5]. QYRA® can be positioned as a supportive nutritional measure alongside established medical therapies like PRP.

Indications: Age 25–35+, early signs of collagen decline, maintenance between clinical treatments. Combine with:

• Superficial chemical peels
• Hyaluronic acid skin boosters QYRA Protocol:
• Long-term cycles (e.g., 3 months on, 1 month off, or continuous daily use). Clinical Rationale:
• Maintains baseline collagen precursor availability to support ongoing skin health and delay the visible signs of intrinsic aging [2].

• Adjunctive Role: QYRA® should be positioned as a supportive nutritional adjunct, not a replacement for primary dermatological procedures or medical treatments.
• Compliance is Critical: Emphasize to patients that consistent, daily use is required. Visible improvements in skin elasticity and hydration typically require 8–12 weeks of continuous supplementation [1].
• Regulatory Status: QYRA® is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration (FDA) or equivalent regulatory bodies. This product is not intended to diagnose, treat, cure, or prevent any disease.

"QYRA® is an evidence-based oral collagen peptide supplement designed to serve as a nutritional adjunct in aesthetic protocols. By providing specific amino acid precursors, it supports the body's natural dermal regeneration and collagen synthesis processes, particularly when combined with collagen-stimulating procedures."

[1] Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014). Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin pharmacology and physiology, 27(3), 113- 119. https://pubmed.ncbi.nlm.nih.gov/24401291/

[2] Myung, S. K., et al. (2025). Effects of Collagen Supplements on Skin Aging. ScienceDirect.
https://www.sciencedirect.com/science/article/abs/pii/S0002934325002839

[3] Miyab, K. B., et al. (2020). The effect of a hydrolyzed collagen-based supplement on wound healing. ScienceDirect.
https://www.sciencedirect.com/science/article/abs/pii/S0305417918306375

[4] Jaiswal, S., et al. (2024). Microneedling in Dermatology: A Comprehensive Review of Percutaneous Collagen Induction Therapy. PMC.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11499218/

[5] Pappelbaum, K. I., et al. (2024). Revealing novel insights on how oral supplementation with bioactive collagen peptides may improve hair health. ScienceDirect.
https://www.sciencedirect.com/science/article/pii/S1756464624001269